The 36-year-old will star opposite 'Friday Night Lights' actor Kyle Chandler in Showtime's drama, reports Deadline.
The show has been described as "a provocative contemporary genre thriller about spirituality, power and politics set against the modern-day political machinations within the Catholic church."
Friel will play Kayla Duffy, the younger sister of Chandler's character Cardinal Thomas Duffy.
Production of the film is set to begin in Rome next month.
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